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The current understanding of METTL3 biology in HCC is summarized, focusing on its structure, assembly within the MTC, regulation of coding and non-coding RNAs, and its roles in driving key oncogenic signaling cascades, such as JAK/STAT3, PI3K/AKT/mTOR, Wnt/β-catenin, Hippo/YAP, Notch, Hedgehog, and epithelial–mesenchymal transition.