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Department Artificial Intelligence in Biomedical Engineering, TUM School of Life Sciences, Department of Experimental Oncology IEO European Institute of Oncology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Technical University of Munich, IRCCS Markus List
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Even "leak-free" protein interaction benchmarks are riddled with non-biological shortcuts that models readily exploit—and standard negative-sampling heuristics often make the bias worse.