Bo Zhang

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Fangyuan Teng (1)Yue-Xi Liu (1)Qi Wu (1)Yong Xu (1)Gang Qin (1)Hong-Xia Li (1)

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Aug 10, 2026

Fangyuan Teng +6Aug 10, 2026

The G-quadruplex ligand CX-5461 inhibits laryngeal cancer via inducing immunogenic cell death and remodeling the tumor immune microenvironment.

Clinical data revealed significantly higher G4 levels in laryngeal tumor tissues compared to adjacent normal tissues, with elevated G4 levels closely associated with poor prognosis, providing a strong preclinical rationale for combining CX-5461 with immune checkpoint blockade in laryngeal cancer treatment.

Fangyuan Teng, Bo Zhang, Yue-Xi Liu +4

Bo Zhang

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Bo Zhang

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