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This review critically examined the application of CRISPR-Cas9 gene editing systems toward achieving functional cure or eradication of human immunodeficiency virus infection, evaluating molecular strategies, preclinical evidence, clinical translation efforts, and obstacles limiting therapeutic implementation.
Current advances in CRISPR-Cas9–mediated gene editing offered a mechanistically rational, potentially curative approach for β-cell restoration in diabetes, though rigorous optimization of delivery vectors, safety profiles, and ethical frameworks remains essential.