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Architecture Design (Transformers, SSMs, MoE) (1)Interpretability & Mechanistic Interp (1)Scientific Discovery & Drug Design (1)

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Yina Cao (1)Jixiu Zhai (1)Jixiu Zhai (1)Junxiao Kong (1)J. Kong (1)Tianchi Lu Cuiying Honors College (1)Tianchi Lu (1)Lanzhou University (1)

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Feb 26, 2026

School of ManagementFeb 26, 2026·also HKU, Lanzhou University, School of Mathematics and Statistics, Shanghai Innovation

MEDNA-DFM: A Dual-View FiLM-MoE Model for Explainable DNA Methylation Prediction

Unlocking the black box of DNA methylation prediction, MEDNA-DFM reveals a "sequence-structure synergy" where GAGG core motifs and upstream A-tract elements cooperate, a hypothesis validated by in silico experiments.

Yina Cao, Jixiu Zhai, Jixiu Zhai +17

Architecture Design (Transformers, SSMs, MoE)Interpretability & Mechanistic Interp Scientific Discovery & Drug Design

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