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This review article examines the role of lipid metabolism in pancreatic cancer progression, highlighting dysregulated cholesterol biosynthesis, altered fatty acid profiles, and lipid-driven immunosuppression. It discusses how these metabolic changes contribute to tumor growth, chemoresistance, and metastasis. The review suggests that targeting lipid pathways may offer new therapeutic strategies for pancreatic cancer.
Targeting lipid metabolism may offer novel therapeutic avenues to overcome chemoresistance and improve outcomes in pancreatic cancer.
Pancreatic cancer (PC) represents one of the most formidable challenges in oncology, necessitating continuous innovation in therapeutic strategies. Owing to its pivotal role in PC progression, lipid metabolism, which is characterized by dysregulated cholesterol biosynthesis, altered fatty acid profiles, and lipid-driven immunosuppression, has received increasing attention. These metabolic aberrations fuel tumour growth, chemoresistance, and metastasis while impairing immune surveillance. By targeting lipid pathways, emerging therapies hold promise for disrupting cancer cell survival and redefining PC treatment paradigms.
