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The paper introduces Praxist, a lineage-centered generational system that transforms experimental artifacts and evaluation outcomes into a structured evidence graph, enabling better tracking of design improvements and their origins. This approach addresses the inefficiencies of current autonomous R&D agents, which often fail to leverage past learnings due to a lack of systematic evidence synthesis. Praxist achieved superior performance on the 75-task MLE-bench suite, securing 60 medals at a significantly reduced cost compared to the Claude Code baseline, demonstrating its effectiveness in both resource efficiency and performance.
Praxist achieves 60 medals on the MLE-bench with an order of magnitude less spending, revolutionizing how autonomous R&D agents can learn from past experiments.
Autonomous R\&D agents now write, run, and improve executable artifacts under automated evaluation---but largely as laboratory instruments: shown on curated benchmarks, with gains that are hard to trace to a cause and costs well above what sustained engineering practice absorbs. The limitation is structural. Most systems treat each attempt as nearly self-contained, so logs, memories, and search trees record what happened without establishing which design element produced an improvement, whether its evidence survived validation, or how it recombines with others. Long campaigns therefore keep re-learning the same lessons. We introduce Praxist, a lineage-centered generational system that converts reproducible artifacts and evaluator outcomes into a typed evidence graph of findings, lane-structured frontiers, and agendas. Separating local artifact construction from cohort-level evidence synthesis lets later attempts inherit validated mechanisms, unresolved claims, and useful constraints, and leaves results attached to an inspectable lineage. On the standardized 75-task MLE-bench suite, the finalized official-grader results give Praxist 60 medals (80.0\%), 49 of them gold, against 55 medals (73.3\%) and 34 gold for a Claude Code baseline on Claude Opus 4.8---at a recorded model spend of US\$3,054 versus US\$38,370, roughly a twelfth of the cost. Four case studies---quantitative trading, LiDAR-inertial-visual SLAM, tokamak magnetic control, and rocket landing---carry the same process into open-ended engineering problems, improving on each task-native baseline in headline accuracy, survival, or resource cost, with the discovery path on record. Stronger artifacts at an order of magnitude less spend, each backed by an auditable lineage, are, to our knowledge, first brought together here: the operating profile production research requires, not the one a benchmark demonstration establishes.
