Search papers, labs, and topics across Lattice.
This paper introduces MSSM+, an extension of Multiscale Structural Mapping (MSSM) that incorporates sulcal depth and cortical curvature at the vertex level for improved Alzheimer's Disease (AD) detection using MRI. They partition the cortical surface into supervertices and employ a Supervertex Vision Transformer (SV-ViT) to enable anatomically informed learning from surface mesh representations. Results show MSSM+ identifies more significant group differences between AD and cognitively normal individuals, achieving a 3% improvement in area under the precision-recall curve compared to MSSM, and demonstrates reduced signal variability across different MRI vendors.
A novel MRI analysis pipeline leveraging supervertex-based vision transformers boosts Alzheimer's detection accuracy and reduces vendor-specific signal variability, potentially enabling earlier and more reliable diagnosis.
Alzheimer's disease (AD) confirmation often relies on positron emission tomography (PET) or cerebrospinal fluid (CSF) analysis, which are costly and invasive. Consequently, structural MRI biomarkers such as cortical thickness (CT) are widely used for non-invasive AD screening. Multiscale structural mapping (MSSM) was recently proposed to integrate gray-white matter contrasts (GWCs) with CT from a single T1-weighted MRI (T1w) scan. Building on this framework, we propose MSSM+, together with surface supervertex mapping (SSVM) and a Supervertex Vision Transformer (SV-ViT). 3D T1w images from individuals with AD and cognitively normal (CN) controls were analyzed. MSSM+ extends MSSM by incorporating sulcal depth and cortical curvature at the vertex level. SSVM partitions the cortical surface into supervertices (surface patches) that effectively represent inter- and intra-regional spatial relationships. SV-ViT is a Vision Transformer architecture operating on these supervertices, enabling anatomically informed learning from surface mesh representations. Compared with MSSM, MSSM+ identified more spatially extensive and statistically significant group differences between AD and CN. In AD vs. CN classification, MSSM+ achieved a 3%p higher area under the precision-recall curve than MSSM. Vendor-specific analyses further demonstrated reduced signal variability and consistently improved classification performance across MR manufacturers relative to CT, GWCs, and MSSM. These findings suggest that MSSM+ combined with SV-ViT is a promising MRI-based imaging marker for AD detection prior to CSF/PET confirmation.
