Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability

Aquaporin-4 gene expression is used as a molecular anchor to reconstruct a whole-brain glymphatic-related topography and link it to vascular physiology, edema, and neurode-generative vulnerability, finding that AQP4 expression is highly organized across the brain, peaking in subcortical, ventral, and periventricular territories.