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This registry study analyzed 198,073 primary THRs from the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) between 2014 and 2023, comparing cementless acetabular components with antioxidant-added highly cross-linked polyethylene (AOXLPE) inserts to those with standard XLPE inserts, both articulating with ceramic or metal femoral heads. The study found that AOXLPE inserts were associated with a significantly lower revision rate after 3 years compared to standard XLPE inserts (HR 0.63, CI 0.47–0.83), particularly for revisions due to loosening, wear, and fracture.
Antioxidant-added highly cross-linked polyethylene (AOXLPE) acetabular inserts in cementless THA are associated with a significantly reduced risk of revision after 3 years compared to standard XLPE inserts.
Background and purpose Adding antioxidant to highly cross-linked polyethylene (XLPE) is proposed to improve oxidation resistance and decrease wear in total hip replacements (THR), but long-term performance is unknown. We aimed to compare the revision rates of THR using cementless acetabular components where the insert was made of either XLPE with antioxidant (AOXLPE) or XLPE, using data from a large national registry. Methods The population was THR from the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) in the 10-year period 2014–2023 with modular cementless acetabular components and ceramic or metal femoral heads used for osteoarthritis. We compared primary THR using XLPE with antioxidant (AOXLPE) acetabular inserts with XLPE acetabular inserts. The outcome measured was all-cause revision. Cumulative percentage revision (CPR) was calculated using the Kaplan–Meier method, and comparisons made using Cox proportional hazards models. Results There were 198,073 THRs, of which 35,309 had AOXLPE inserts. There were 769 and 4,327 revisions with AOXLPE and XLPE inserts, respectively. While there was no early difference, the AOXLPE group had a lower revision rate after 3 years (HR 0.64, 95% confidence interval [CI] 0.48–0.84). When adjusted for multiple factors the AOXLPE group still had a lower revision rate after 3 years (HR 0.63, CI 0.47–0.83). Revisions for loosening, wear-related causes, and fracture were proportionately lower in the AOXLPE group, but no difference was found with revisions for dislocation/instability or infection. Conclusion While there was no early difference, THR with AOXLPE acetabular inserts had a lower revision rate after 3 years than XLPE. This suggests a possible clinical benefit using AOXLPE but the difference may, in part, be related to the associated femoral or acetabular components.
