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This review examines the transformative role of quantum sensors, particularly optically pumped magnetometers (OPMs) and nitrogen-vacancy (NV) centers in diamond, in advancing molecular and materials analysis. By leveraging the extreme magnetic sensitivity of OPM ensembles alongside the atomic-scale resolution of NV centers, the study highlights their applications in various analytical techniques, including nanoscale NMR spectroscopy and real-time reaction monitoring. The findings underscore the potential of these quantum technologies to revolutionize high-throughput chemical assays and non-destructive diagnostics in materials science, paving the way for their routine use in addressing complex analytical challenges.
Quantum sensors could redefine molecular analysis by combining extreme sensitivity with atomic-scale resolution, enabling unprecedented insights in chemistry and materials science.
The advancement of chemistry and materials science relies on transformative analytical tools which can overcome the sensitivity, spatial resolution, and throughput limitations of conventional techniques. This review explores the application of quantum sensors - specifically optically pumped magnetometers (OPMs) and nitrogen-vacancy (NV) centers in diamond - as robust platforms for molecular and materials analysis. We contrast the extreme magnetic sensitivity of macroscopic OPM ensembles with the atomic-scale resolution and multimodal capabilities of solid-state NV centers. We highlight their deployment in zero- to ultralow-field and nanoscale NMR spectroscopy, real-time reaction monitoring, and transient radical and pH detection. Furthermore, we discuss their integration into high-throughput chemical assays and non-destructive materials diagnostics, such as operando battery monitoring. With the ongoing commercialization of these technologies and advances in quantum-enhanced sensitivities, quantum sensors are poised to routinely address complex real-world analytical challenges.
