Search papers, labs, and topics across Lattice.
TRACE-Seg3D introduces a counterfactual context auditing framework designed to enhance the robustness of 3D glioma segmentation models against variations in imaging context. By systematically varying imaging conditions while preserving lesion-relevant evidence, the framework quantifies prediction stability and identifies context-sensitive failure modes that traditional metrics overlook. Experiments demonstrate that TRACE-Seg3D achieves competitive performance on both in-distribution and cross-domain benchmarks, highlighting its potential for improving reliability in medical image segmentation.
Context-sensitive failures in glioma segmentation models can be identified and quantified, revealing vulnerabilities that standard metrics miss.
Medical image segmentation models can achieve strong benchmark performance while remaining sensitive to scanner, protocol, and institutional variation. These context shifts alter image appearance without changing the underlying lesion, allowing models to exploit nuisance cues that Dice and HD95 fail to expose. We present TRACE-Seg3D, a counterfactual context auditing framework for robust 3D medical image segmentation. TRACE-Seg3D preserves lesion-relevant evidence and systematically varies imaging context to quantify prediction stability under controlled context shifts. The framework pairs each segmentation with audit evidence for context sensitivity and anatomical plausibility, enabling case-level reliability assessment beyond overlap-based evaluation. Experiments on BraTS and UTSW glioma segmentation benchmarks demonstrate competitive in-distribution and cross-domain performance. TRACE-Seg3D also exposes context-sensitive failure modes missed by conventional metrics. These results establish counterfactual context auditing as a practical route toward transparent and reliable 3D medical image segmentation under distribution shift. Our code is available at https://github.com/danleneurocom/Counterfactual-Representation-Network.
