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Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA, Richard T Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY, USA
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An approach to potentially cure myeloproliferative neoplasms is established by proving mutant calreticulin to be a MPN stem cell marker that can be targeted by CAR-T cells to selectively wipe out disease in preclinical models of human MPNs.
