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In recent years, the relationship between organic brain lesions and new-onset criminal behavior has gradually attracted attention. This article reviews relevant research, and focuses on the main manifestations and possible mechanisms of new-onset criminal behavior related to organic brain lesions and its significance in responsibility identification and practical response. Existing studies show that such behaviors are heterogeneous in nature, but may be manifested as aggression, theft, traffic violations, inappropriate sexual behavior and other serious deviations, and are related to changes in behavioral regulation, impulse control, social cognition and judgment ability. This article believes that the understanding of such behavior should not be limited to the superficial judgment of whether it is illegal or not, but should be analyzed more carefully in combination with the characteristics of lesions, the process of behavioral change and the clues of neuropsychological function. The discussion of this issue not only helps to deepen the understanding of the relationship between brain pathology and abnormal behavior, but also provides some reference for judicial judgment, clinical evaluation and practical management.