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The present study delves into the psychosocial impact of Perimenopause and Menopause on the mental health of working women in Coimbatore District, Tamil Nadu. It explores the effects of hormonal fluctuations, psychosocial factors, coping strategies, and support systems on mental health during this stage. Employing an explanatory research design, it aims to understand causal relationships and complex interactions, elucidating reasons behind mental health changes. The qualitative method of case study was used for data collection, involving a sample of 10 working women under 50 experiencing menopause or its transitional phase. Probability sampling was employed to ensure generalizability. The Findings reveal a correlation between hormonal changes (e.g., decreased Estrogen levels) and symptoms like Depression, Anxiety, mood swings, and cognitive changes. Psychosocial stressors from work, family, and societal attitudes towards aging significantly impact mental health during this transition. The study underscores the need for tailored interventions and support programs to address women's specific needs during perimenopause and menopause, enhancing mental health outcomes and overall well-being. The study concludes with the importance of understanding the multifaceted nature of menopausal experiences, considering both biological and psychosocial factors. By recognizing the challenges faced by working women during this transition, appropriate interventions can be developed to support their mental health effectively as well as it contributes valuable insights to the development of holistic approaches aimed at promoting well-being and resilience among women navigating perimenopause and menopause in Coimbatore District.